Implantation of a Crosslinked Salmon Collagen Sponge Disc with Osteogenic Protein-1 (BMP-7) Induces Spontaneous Hyaline Cartilage Regeneration in a Large Osteochondral Defect
ثبت نشده
چکیده
Hyaline Cartilage Regeneration in a Large Osteochondral Defect Mori, H; Kondo, E; Kawaguchi, Y; Kitamura, N; Nagai, N; Munekata, M; Iida, H; +Yasuda, K +Department of Sports Medicine, Hokkaido University School of Medicine, Sapporo, Japan; Department of Orthopaedic Surgery, Kansai Medical University, Osaka, Japan; Department of Translational Research, Tohoku University School of Medicine, Sendai, Japan; Divison of Biotechnology and Macromolecular Chemistry, Hokkaido University School of Engineering, Sapporo, Japan; [email protected]
منابع مشابه
Development of a salmon-derived crosslinked atelocollagen sponge disc containing osteogenic protein-1 for articular cartilage regeneration: in vivo evaluations with rabbits
BACKGROUND We have developed crosslinked salmon-derived atelocollagen sponge, which has a denaturation temperature of 47 degrees Celsius. The purpose of this study is to evaluate the fundamental in vivo efficacy of the osteogenic protein (OP) -1 containing salmon-derived collagen sponge disc (SCS) on cartilage regeneration, using a rabbit model. METHODS A total of 24 rabbits were used in this...
متن کاملIn vivo effects of isolated implantation of salmon-derived crosslinked atelocollagen sponge into an osteochondral defect.
We have developed crosslinked salmon-derived atelocollagen (SC) sponge, which has a denaturation temperature of 47°C. Sixty-four knees of 32 mature rabbits were randomly divided into 4 groups after creating an osteochondral defect in the femoral trochlea. Defects in Groups I, II, and III were filled with the crosslinked SC sponge, the crosslinked porcine collagen (PC) sponge, and the non-crossl...
متن کاملSpontaneous hyaline cartilage regeneration can be induced in an osteochondral defect created in the femoral condyle using a novel double-network hydrogel
BACKGROUND Functional repair of articular osteochondral defects remains a major challenge not only in the field of knee surgery but also in tissue regeneration medicine. The purpose is to clarify whether the spontaneous hyaline cartilage regeneration can be induced in a large osteochondral defect created in the femoral condyle by means of implanting a novel double-network (DN) gel at the bottom...
متن کاملEffects of culture on PAMPS/PDMAAm double-network gel on chondrogenic differentiation of mouse C3H10T1/2 cells: in vitro experimental study
BACKGROUND Recently, several animal studies have found that spontaneous hyaline cartilage regeneration can be induced in vivo within a large osteochondral defect by implanting a synthetic double-network (DN) hydrogel, which is composed of poly-(2-acrylamido-2-methylpropanesulfonic acid) (PAMPS) and poly-(N,N'-dimethyl acrylamide) (PDMAAm), at the bottom of the defect. However, the effect of hyd...
متن کاملOsteochondral regeneration with a novel aragonite-hyaluronate biphasic scaffold: up to 12-month follow-up study in a goat model
BACKGROUND The regeneration of articular hyaline cartilage remains an elusive goal despite years of research. Recently, an aragonite-hyaluronate (Ar-HA) biphasic scaffold has been described capable of cartilage regeneration over a 6-month follow-up period. This study was conducted in order to assess the fate of the regenerated osteochondral tissue in a 12-month-long validated caprine model. H...
متن کامل